I don't talk about it often but I have found myself at certain times in my life asking God this very question:
Will this come between us?
When I was younger, this was usually reserved for pressing decisions. Now it's used for most, if not all decisions. I don't always get it perfectly but it's saved me from a lot of unnecessary pain and issues. Sometimes I struggled with making decisions that could possibly separate me from God. This, is where the God-factor kicks in. If I ever drifted too far, ever the best chess player, He definitely knew how to draw me back in. He wouldn't let me go and eventually I stayed.
So if God isn't in it, then I know it can't be what's best for me. When I want the latter I know He'll just reel me back in because He's amazing like that. With God comes safety, joy, peace, self-control, other fruits of the spirit, freely given gifts, etc. With God comes satisfaction and fulfillment. Everything He has shown me, allowed, and brought me from along the way is all thanks to Jesus.
At the end of the day though that question remains a staple for me:
Will this come between us?